The Klinaklini River is one of the major rivers of the Pacific Ranges section of the Coast Mountains in British Columbia. It begins in the northern basins of the Pantheon Range to the north of Mount Waddington and briefly heads northeast onto the Chilcotin Plateau before bending around northwestwards to turn around south, reaching its mouth at the head of Knight Inlet after c.200 km. The brief but voluminous West Klinaklini River (7 km only) joins the Klinaklini in its lower reaches, and is the meltwater from the Klinaklini Glacier, the main tongue of the vast Ha-Iltzuk Icefield (Silverthrone Glacier), which lies west of the Klinaklini. To the east of the Klinaklini in the same area is the Waddington Range.
A different spelling of Klinaklini is Kleena Kleene, which is the name of a recreational community on the river just below its exit from the Pantheon Range onto the Chilcotin Plateau. The area of Kleena Kleene is one where the Klinaklini, Homathko and Chilanko River basins share the same stretch of plateau.